Thursday, November 3, 2011

Tamsulosin (Oral Route)


US Brand Names

  • Flomax

Description

Tamsulosin is used to treat the signs and symptoms of Tadaforce benign enlargement of the prostate (benign prostatic hyperplasia or BPH). Benign enlargement of the prostate is a problem that can occur in men as they get older. The prostate gland is located below the bladder. As the prostate gland enlarges, certain muscles in the gland may become tight and get in the way of the tube that drains urine from the bladder. This can cause problems in urinating, such as a need to urinate often, a weak stream when urinating, or a feeling of not being able to empty the bladder completely.
Tamsulosin helps relax the muscles in the prostate and the opening of the bladder. This may help increase the flow of urine or decrease the symptoms. However, tamsulosin will not shrink the prostate. The prostate may continue to get larger. This may cause the symptoms to become worse over time. Therefore, even though tamsulosin may lessen the problems caused by enlarged prostate now, surgery still may be needed in the future.
This medicine is usually given only to men. It is not normally given to women or children.
This medicine is available only with your doctor's prescription.
This product is available in the following dosage forms:
  • Capsule

Before Using

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Allergies
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Pediatric
Use of tamsulosin in children is not recommended.
Geriatric
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tamsulosin in the elderly.
Pregnancy
Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.
Breastfeeding
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Drug Interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
  • Atazanavir
  • Clarithromycin
  • Indinavir
  • Itraconazole
  • Ketoconazole
  • Nefazodone
  • Nelfinavir
  • Ritonavir
  • Saquinavir
  • Telithromycin
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
  • Acebutolol
  • Alprenolol
  • Atenolol
  • Betaxolol
  • Bevantolol
  • Bisoprolol
  • Bucindolol
  • Carteolol
  • Carvedilol
  • Celiprolol
  • Cimetidine
  • Dilevalol
  • Esmolol
  • Labetalol
  • Levobunolol
  • Mepindolol
  • Metipranolol
  • Metoprolol
  • Nadolol
  • Nebivolol
  • Oxprenolol
  • Paroxetine
  • Penbutolol
  • Pindolol
  • Propranolol
  • Sildenafil
  • Sotalol
  • Tadalafil
  • Talinolol
  • Tertatolol
  • Timolol
  • Vardenafil
Other Interactions
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Other Medical Problems
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
  • Cataract surgery—An eye problem called Intraoperative Floppy Iris Syndrome (IFIS) has occurred in patients who are taking or who have recently taken this medicine when they are having cataract surgery. You should tell your ophthalmologist (eye doctor) before your surgery if you are taking or have taken tamsulosin in the past 9 months.
  • Kidney disease or
  • Liver disease—Effects may be increased because of slower removal of the medicine from the body.
  • Postural hypotension (low blood pressure) or
  • Priapism (painful or prolonged erection of the penis) or
  • Prostate cancer—Use with caution. May make these conditions worse.
  • Sulfa drug (antibiotics such as sulfamethoxazole/trimethoprim [e.g., Bactrim®, Septra®]) allergy—An allergic reaction to tamsulosin has been rarely reported in patients with sulfa allergy. If you have ever had a serious or life-threatening sulfa allergy, you should tell your doctor before taking tamsulosin.

Generic Flomax


Generic for Flomax: An Overview

Flomax® (tamsulosin hydrochloride) is a prescription medication that has been licensed as a treatment for an enlarged prostate. An enlarged prostate is also known as benign prostatic hyperplasia, benign prostatic Lifta hypertrophy, or BPH. Flomax is part of a class of drugs known as alpha blockers.
 
Brand-name Flomax is manufactured by Boehringer Ingelheim Pharmaceuticals, Inc. Generic Flomax is also available.
 

Strengths of Generic Flomax

Like brand-name Flomax, the generic version comes in one strength -- tamsulosin 0.4 mg capsules.
 

Who Makes Generic Flomax?

Generic Flomax is made by various manufacturers, such as:
 
  • Actavis
  • Global Pharmaceuticals
  • Mylan Pharmaceuticals
  • Sandoz
  • Teva Pharmaceuticals
  • UDL Laboratories.
  •  

Is Generic Tamsulosin as Good as Flomax?

All generic medications must undergo certain tests to compare them to brand-name medications. The U.S. Food and Drug Administration (FDA) then looks at these tests to decide if the generics are equivalent to the brand-name medications and assigns each generic a rating. An "AB" rating means that the FDA has determined that a generic medication is equivalent to a brand-name medication. Generic tamsulosin capsules have an "AB" rating, meaning they should be equivalent to Flomax.
 
However, generic medications are allowed to have different inactive ingredients than the brand-name medication. This might include fillers, dyes, or other ingredients that may cause problems for people withallergies or sensitivities.

Flomax Side Effects: An Introduction

As with any medicine, there are possible side effects associated with Flomax®(tamsulosin hydrochloride). However, not everyone who takes this drug will experience side effects. In fact, most people tolerate Flomax well. When side effects do occur, in most cases they are minor, meaning they require no treatment or are easily treated by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with Flomax. Your healthcare provider can discuss a more complete list of Flomax side effects with you.)
 

Common Side Effects of Flomax

Flomax has been thoroughly studied in clinical trials, with thousands of people being evaluated. In these studies, side effects occurring in the group of people taking the drug are always documented and compared to the side effects that occur in a similar group of people not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
 
Based on these studies, the most common Flomax side effects include:
 
  • Abnormal ejaculation -- occurring in up to 18.1 percent of people(see Flomax Sexual Side Effects)
  • Runny or stuffy nose -- in up to 17.9 percent
  • Dizziness -- in up to 17.1 percent
  • Infections, including the common cold or flu -- in up to 10.8 percent
  • General body pain -- in up to 8.5 percent
  • Back pain -- in up to 8.3 percent
  • Diarrhea -- in up to 6.2 percent
  • Sore throat -- in up to 5.8 percent.
     
There are several less common side effects of Flomax that occurred in 1 to 5 percent of people:
 
  • Increased coughing
  • Sleepiness
  • Chest pain
  • Upset stomach (nausea)
  • Sinus infection (sinusitis)
  • Decreased sex drive (libido)
  • Blurred vision
  • Tooth problems
  • Trouble sleeping (insomnia)
  • Spinning sensation (vertigo).